Long-Term Use of PPIs Not Associated with Cognitive Decline

A study published in Clinical Gastroenterology and Hepatology did not associate long-term proton pump inhibitor (PPI) use with cognitive decline in middle-aged and older individuals, reports MedPage Today . "Neither baseline cognitive scores of more than 7,800 middle-aged and older Danish twins, nor follow-up data on more than 4,000 of these twins, indicated that use of this class of drugs was correlated to cognitive decline," the researchers note. "These findings were supported by results of within-pairs analyses of twins discordant for cognitive scores (baseline) or cognitive decline (follow-up)." A total of 7.4 percent of all adults in Demark used PPIs in 2014, and 262 twins in one study and 299 of twins in a second study had used PPI in the two-year period prior to baseline. Pre-baseline PPI use was associated with a higher prevalence of comorbidities, and a more frequent use of non-PPI medications, suggesting a worse general health background status versus twins with no PPI use in the two-year period. Aging twins with the highest pre-baseline PPI use had higher adjusted scores than non-users, and the cumulative PPI dose within two years before baseline participation did not influence the attained composite cognitive scores in either cohort.