Reducing Early Brain Inflammation Could Slow Alzheimer's Progression

An animal study published in the FASEB Journal found that Alzheimer's disease progression could be slowed by decreasing inflammation in the brain before memory problems and cognitive impairment develop, reports EurekAlert . "Starting an intervention at the earliest stage of the disease, when cellular and molecular alterations have already been triggered but major damage to the brain has not yet occurred, could offer a way to reduce the number of people who go on to develop full Alzheimer's dementia," said University of Rome Professor Caterina Scuderi. The outcomes of the animal study suggested that rebalancing neuroinflammation in specimens that exhibit altered neuroinflammatory parameters could be helpful. "Our results help demonstrate that neuroinflammation in Alzheimer's disease is an extremely complex phenomenon that can change over the disease's progression and varies based on factors such as affected brain area," noted Scuderi. "We hope that these findings will prompt scientists to further investigate neuroinflammation at the earliest stages of the disease, which may represent an important pharmacological target."